"Cancer as a Metabolic Disease" is a comprehensive treatise that presents the argument that cancer is primarily a metabolic disease, not a genetic one. The author, a biochemical geneticist, discusses the role of energy metabolism in cancer's origin and progression, and proposes that targeting the defective energy metabolism of tumors could lead to more effective and less toxic treatment strategies.
The intended audience for the book "Cancer as a Metabolic Disease" is likely professionals and students in the medical and scientific fields, particularly those interested in or working on cancer research, as well as individuals seeking in-depth knowledge about the metabolic aspects of cancer.
Buy the book
Cancer is predominantly a metabolic disease, caused by mitochondrial dysfunction and impaired respiration, rather than a genetic one.
Many cancer models fail to accurately replicate human cancers, particularly metastasis.
Cancer cells, due to their faulty mitochondria and impaired respiration, rely heavily on inefficient fermentation for energy.
Some scientists suggest that oxidative phosphorylation may still function in cancer cells, necessitating more rigorous experiments to clarify this issue.
Cancer cells adapt to low oxygen environments by using mitochondrial amino acid fermentation, particularly of glutamine, for energy production.
Impaired cellular respiration triggers a stress response that, while initially protective, can lead to genomic instability and cancer development in the long term.
Normal mitochondrial respiration can suppress cancer development, suggesting that mitochondrial dysfunction, not nuclear mutations, is the primary cause of cancer.
The metabolic switch to fermentation is a survival strategy for cancer cells, allowing them to avoid apoptosis and achieve limitless replication.
Metastasis, the spread of cancer cells, may be driven by mitochondrial dysfunction in myeloid immune cells, specifically macrophages.
Cancer progression appears to align more with Lamarck's theory of acquired inheritance than Darwin's natural selection, and should be treated as a metabolic disease, not a genetic one.
Current cancer treatments are limited in effectiveness and often have severe side effects, but targeting tumor cell energy metabolism offers a promising, less toxic alternative.
Non-toxic dietary and metabolic therapies, such as the calorie-restricted ketogenic diet, effectively manage cancer progression and metastasis.
"Cancer as a Metabolic Disease" by Thomas Seyfried presents a comprehensive argument that cancer should be viewed primarily as a metabolic disease rather than a genetic one. Seyfried argues that the root cause of cancer is a defect in cellular energy production due to damaged respiration in the mitochondria, leading to increased fermentation for energy production. This shift in energy metabolism is a fundamental aspect of cancer that is common across various types of the disease. Seyfried suggests that by understanding and targeting this metabolic dysfunction, more effective and less toxic cancer treatments can be developed.
Thomas Seyfried is an American biologist and professor of biology at Boston College. He is known for his research in genetics, neurochemistry, and cancer, particularly his work on the metabolic theory of cancer.
The Song of the Cell is a book that explores the complexities of life through the lens of its simplest unit, the cell, aiming to understand its anatomy, physiology, behavior, and interactions. It chronicles the history of cellular discovery, the development of cellular technologies, and the transformation of medicine through our understanding and manipulation of cells.
The Experience Machine is a book that explores the concept of the human brain as a prediction machine, examining how our minds predict and shape our reality. It delves into the impact of these predictions on our experiences, emotions, and actions, and discusses potential ways to manipulate or "hack" our predictive minds.
"Consciousness Beyond Life" is a book that explores the concept of consciousness, particularly in relation to near-death experiences, and challenges the materialist scientific paradigm that consciousness is solely a product of the brain. It delves into various forms of consciousness, including nonlocal consciousness, and discusses the relationship between consciousness and the brain, raising questions about consciousness during sleep, coma, brain death, and after confirmed death.
Das Buch "Cannabis und Cannabidiol (CBD) richtig anwenden" handelt im Allgemeinen von der medizinischen Anwendung von Cannabis und CBD, einschließlich ihrer Wirkungen, Nebenwirkungen und rechtlichen Aspekte.
"Delusions of Gender" is a book by Cordelia Fine that critically examines and challenges the traditional stereotypes and biases about the differences between male and female brains, arguing that they are largely influenced by societal expectations and norms.
The book "Evidence" by Howard S. Becker explores the process of scientific inquiry, focusing on how social scientists use data, evidence, and ideas to form theories and convince others of their validity. It discusses the methods of data collection, the transformation of data into evidence, and the role of ideas in interpreting evidence.
