The story centers on the unusual friendship between Jeff and Chipper, who find trust and support in each other despite being alone. They stick together unconditionally despite being pursued by a secret organization.

The book raises important questions about the treatment of animals and the limits of science, critically examining genetic manipulation of animals for human purposes and prompting reflection on responsibility and morality.

Both Jeff and Chipper must show great courage throughout the story. Jeff, as an orphan, finds new self-confidence through Chipper, while Chipper fights bravely for his freedom and friendship despite past mistreatment.