Afi's journey from a small-town seamstress to a woman navigating the complexities of life in Accra is a powerful exploration of independence and self-discovery. Her struggle to find her own voice and make decisions for herself, despite societal and familial pressures, is a central theme that resonates deeply with readers.

The novel delves into the expectations placed on women in Ghanaian society, particularly in terms of marriage and family. Afi is expected to be a dutiful wife who cooks, cleans, and respects her husband, but she challenges these traditional roles, highlighting the ongoing struggle for gender equality.

At its core, "His Only Wife" is a story about love and relationships. Afi's arranged marriage to Elikem and her subsequent interactions with him and his family reveal the complexities of love, loyalty, and trust. The novel examines how relationships can be influenced by external factors and the importance of staying true to oneself.