Two monumental molecules were introduced in the mid-20th century: LSD, a serendipitous scientific discovery, and psilocybin, a natural compound used by indigenous peoples for centuries. These substances emerged during the atomic age, sparking connections between them and the era's new energies. Initially, psychedelics like LSD and psilocybin were hailed in 1950s psychiatry as breakthrough treatments for mental disorders and became symbols of counterculture's quest for expanded consciousness. However, societal backlash by the late 1960s led to their prohibition.

In the 1990s, a resurgence of interest in the therapeutic potential of psychedelics began, now supported by controlled research highlighting benefits in treating mental health issues and facilitating profound personal insights. The author, Michael Pollan, shares his initial skepticism toward psychedelics, stemming from his materialistic and cautious outlook. Yet, intrigued by emerging studies, he recognizes the value in exploring consciousness beyond conventional boundaries, seeing psychedelics as tools for insight and healing, albeit with caution. Embracing both skepticism and openness, he explores the intersection of science, spirituality, and consciousness, seeking a balanced understanding of psychedelics' role in human experience.