Florentino Ariza's lifelong devotion to Fermina Daza, even after her marriage to another, forms the emotional core of the novel. This isn't simply romantic infatuation; it's an all-consuming love that transcends physical intimacy, societal expectations, and the passage of time itself. Florentino's unwavering belief in their eventual reunion fuels his actions and choices, demonstrating the sheer force of love's enduring power.

Fermina's decision to marry the respected Dr. Juvenal Urbino instead of Florentino highlights the often-conflicting forces of love and practicality. While Florentino represents passionate, all-consuming love, Juvenal embodies stability, social standing, and the promise of a comfortable life. This conflict reflects the complex realities of love and relationships, particularly within a society bound by tradition and societal expectations.

Marquez masterfully weaves the theme of time throughout the narrative, showcasing how it shapes love, relationships, and individuals. We witness Florentino and Fermina's love evolve through youth, middle age, and into their twilight years. The story doesn't shy away from depicting the physical and emotional effects of aging, yet it simultaneously celebrates the possibility of finding love and connection at any age.