The novel emphasizes the captivating and transformative power of stories. Vida's tales are shown to possess a unique hold on their listeners, capable of shaping perceptions and blurring the lines between reality and fiction. This theme is further highlighted through Margaret's own journey as a biographer, where she navigates the complexities of truth, memory, and narrative construction.

The Thirteenth Tale is steeped in secrets, from the mysteries surrounding the March family to the long-guarded truth about Vida Winter's past. The characters grapple with the weight of concealed identities and the ramifications of revealing hidden truths. This theme explores the intricate connection between past and present, and the enduring impact of secrets on individual lives.

The novel delves into the complexities of familial relationships, exploring themes of love, betrayal, and forgiveness. The unconventional dynamics within the March family, coupled with Margaret's own longing for connection, highlight the multifaceted nature of family and the human need for belonging. Despite their dysfunctional relationships, there's an undeniable pull towards understanding and connection.