The novel centers on a passionate love story between Nena, a healer, and Néstor, a vaquero, set against the Mexican-American War. Their childhood love, broken by trauma, must be rekindled while facing the devastating consequences of conflict and choosing between personal desires and the greater good.

The story explores the thin line between monsters and men, with vampires symbolizing societal darkness while human characters struggle with their own inner demons. This duality questions the true nature of monstrosity.

Set during national turmoil, the novel explores cultural identity and resistance as characters navigate between Mexican tradition and U.S. influence. The vampires represent larger forces threatening their way of life, leading to a fight for survival and cultural preservation.