The main plot revolves around Eddie Brock and his symbiote partner as they confront an ancient evil that emerges from beneath New York City's streets. This threat challenges not only their physical abilities but also the core of their relationship, with the added complexity of Miles Morales' Spider-Man entering the conflict.

Miles Morales' Spider-Man adds a tense dynamic to the narrative by becoming a significant force in the conflict. His presence creates additional layers of tension and interaction between the characters, enriching the storyline.

Donny Cates' reimagining of Venom is unique due to his innovative storytelling that pushes the boundaries of the symbiote mythology. Along with Ryan Stegman's dynamic artwork, the story combines action-packed sequences with deep character development, challenging and expanding the understanding of Venom's origins and purpose.