The book delves into the intricate relationships within Sedaris's family, highlighting both the love and the tension that exist among them. The stories capture the essence of family gatherings, with all their quirks and idiosyncrasies, making readers reflect on their own familial bonds.

A central theme in 'Calypso' is Sedaris's contemplation of aging and the inevitability of death. Through his humorous and poignant observations, he explores the physical and emotional changes that come with middle age, offering a candid and relatable perspective on this stage of life.

Sedaris has a unique talent for finding humor in everyday situations. Whether it's a simple family vacation or a mundane conversation, he manages to turn the ordinary into something extraordinary and laugh-out-loud funny. This theme underscores the book's ability to entertain while also providing deeper insights into the human experience.